Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Synthesis and biological evaluation of some new het erocyclic derivatives incorporating napthofuran moiety

Author(s): Milan Sharda and G. D. Acharya

Naphtho[2,1-b]furan-2-carbohydrazide (1) undergoes facile condensation with aromatic aldehydes to affo rd the corresponding N-arylidenenaphtho[2,1-b]furan-2-carb ohydrazide(3a-h) in good yields. Cyclocondensation of compounds (3a-h) with thioglycolic acid yields N-(4 -oxo-2-arylthiazolidin-3-yl) naphtho[2,1-b]furan-2- carboxamide (4a-h). The structures of these compoun ds were established on the basis of analytical and spectral data. All the newly synthesized compounds were eval uated for their antibacterial and antifungal activi ties


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