In view of potent antimicrobial and anti-inflammato ry activities exhibited by quinazoline-4-(3H)-one, an efficient synthesis of novel quinazolone analogs fused with a zetidin-2-ones 4a-j has been established. Thus, condensation of 2-phenyl-3-amino quinazolin-4-one 2 with various aromatic aldehydes afforded quinazolo ne fused Schiff bases 3a-j which on further cycloaddition with chloroacetyl ch loride in the presence of triethylamine catalyst yi elded title compounds. All the synthesized compounds were scree ned for in vivo anti-inflammatory activity using th e carrageenin-induced paw edema method in rats.
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