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Synthesis and biological evaluation of some newer triazole based Schiff├ó┬?┬?s bases | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Synthesis and biological evaluation of some newer triazole based Schiff├ó┬?┬?s bases

Author(s): P. P. Munj, R. R. Somani, A.V. Chavan

Synthesis of some newer Schiff’s bases from 1, 2, 4-triazole were achieved. 1, 2, 4-triazole was converted to ethyl-5-N’-(1, 2, 4-triazolyl)-acetate 1 using ethyl bromoacetate. It was then converted to corresponding hydrazide 2, which upon further treatment with various aromatic aldehydes afforded Schiff’s bases 3a-3h. Structures of various Schiff’s bases 3a-3h were established on the basis of elemental analyses and spectral data. The targeted compounds were obtained in good yields and subjected to antibacterial activity test against pathogenic bacteria at two different concentrations compounds 3b and 3e showed promising antibacterial activity compared to other analogues.


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