Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

Abstract

Synthesis and Biological Evaluation of Substituted Pyrazoline Derivatives Bearing 3,4,5-Trimethoxyphenyl Moiety as Anticancer, Anti-inflammatory and Antioxidant Agents

Author(s): Sadanand N Shringare, Hemant V Chavan, Pravin S Bhale, Sakaram B Dongare, Yoginath B Mule, Mahesh P Lendve, Iranna Todkari, Babasaheb P Bandgar

In search for a potent agent, 3-(4-nitrophenyl)-5-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1H-pyrazole 3a with the chalcone scaffold (E)-1-(4-nitrophenyl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one 2a was synthesized to design 3-(4-nitrophenyl)-1-substituted phenyl-5-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1H-pyrazole 4a-e and 3-(4-nitrophenyl)-N-substituted phenyl-5-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide 5a-e. IR, 1H NMR and mass spectral analysis, confirmed the structure of compounds. All compounds evaluated for in vitro anticancer, anti-inflammatory and antioxidant activity. Among the series, compound 3a and 5b found to possess potent anticancer activity against breast carcinoma (MCF7). The data for antioxidant activity revealed that, compound 4b and 5c exhibited significant 1,1-Diphenyl-2-picryl-hydrazyl (DPPH) radical scavenging activity as compared to the standard drug ascorbic acid. Compounds 2a, 4d and 5b showed excellent nitric oxide radical scavenging activity. While, compounds 2a, 4e, 5a, 5b and 5c showed pronounced superoxide radical scavenging activity, However all the compounds tested for H2O2 radical scavenging activity were devoid of activity. Additionally, compounds 4b, 4d, 4e and 5b showed good anti-inflammatory activity.


PDF

FIND ARTICLES
SCImago Journal & Country Rank
 
Erkek öyle sert ve acımaz sikiyor ki bayan çaresiz bir şekilde tırtıl misali sikiş yataktan aşağı doğru kayıyor fakat hem adam hemde kadın aşırı mobil porno derecede zevk alıyorlar Uzun zamandır karısı ile ilgili planları olan türk porno adam onu başkaları sikerken hayal ediyor bu durumu karısından sikiş izle gizliyordu fakat bir gün adamın moralinin bozuk olduğunu anlayan karısı sikiş ona ne olduğunu sordu ve adamda ona her şeyi anlatmıştı karısı bu porno resim durumdan Büyük zenci yarağı sevenler için özel olarak eklenmiş videomuz türk porno kalın ve damarlı zenci siki arayıp bulamayanlar için özel olarak sikiş izle yayınlanmıştır filmde ise sarışın zengin sürtük büyük mobil sikiş kalın damarlı alet sevdiğini bir çok kez dile getirmiş