Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Synthesis and biological evaluation of triazine derivatives

Author(s): Surendra Nath Pandeya, Rajeev Kumar, Ashish Kumar Pathak, Gopal Nath

Some new triazine derivatives (4a-4l) have been synthesized. The newly synthesized compounds were characterized on the basis of elemental analysis, IR and 1H-NMR spectra. All the synthesized compounds were tested for their antibacterial activity against 20 strains of Gram positive and Gram negative bacteria. Among the compounds tested, the compounds 4a & 4l showed good antimicrobial activity in comparison to standard sulphamethoxazole. Compound 4l was found to be most active in the series against H. pylori with MIC 25 μg/mL.


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