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Synthesis and biological investigation of isoxazolo[4,5-e][1,2,4]triazine derivatives | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Synthesis and biological investigation of isoxazolo[4,5-e][1,2,4]triazine derivatives

Author(s): Ajay N. Ambhore,Vishwash D. Surywanshi, Rahul D. Kamble, Shrikant V. Hese,Pratima P. Mogle, Shital S. Kadam and Bhaskar S. Dawane

In present report we have successfully synthesized isoxazolo[4,5-e][1,2,4]triazine derivatives in quantitative yields using PEG-400 as green reaction medium. The synthesized compounds were screened for antimicrobial against selected bacterial strains. The results of anti-bacterial activity revealed that some of the compounds were found to be active antibacterial agent.


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