Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Synthesis and biological screening of 1,4-dihydropyridine derivatives containing benzothiazolyl moiety

Author(s): Mithlesh, Pawan kumar Pareek, Ravikant and KG Ojha

A series of N-(6-nitrobenzothiazolyl)-2,3,5,6-tetrasubstituted-4-(aryl)-1,4-dihydropyridines were synthesized by reaction of 2-amino-6-nitrobenzothiazole, aromatic aldehyde and active methylene compound in methanol by conventional, as well as, microwave irradiation (solvent free and solid support) methods. The microwave irradiation technique gives better yield in shorter reaction time. Among solid supported microwave irradiation better yields are obtained in acidic alumina as compared to silica, neutral alumina, and basic alumina. All compounds were tested for antibacterial and antifungal activities and results have been compared with standard drugs. Entomological activities and Antiproliferative activity of some synthesized compound were also tested. The results showed that a change in the substitution pattern in 1,4- dihydropyridine derivatives may cause a marked effect on their antimicrobial activity.


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