Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Synthesis and biological screening of 2-(4-methylpiperazin-1-yl methyl)-1-(arylsulfonyl)-1H-indole derivatives as 5-HT6 receptor ligands: Part II

Author(s): Ramakrishna V. S. Nirogi,Amol D. Deshpande, Ramasastri Kambhampati, Jagadishu Babu Konda, Bandyala Thrinath Reddy, Gudla Parandhama, B. Venugopala Rao, Anil K. Shinde, P. K. Dubey

As a part of our ongoing research to develop novel and selective 5-HT6 receptor antagonists, a new series of 2-(4- methylpiperazin-1-yl methyl)-1-(arylsulfonyl)-1H-indole derivatives were designed to study the effect of two ionisable basic centers on the 5-HT6 receptor binding affinity. The synthesis and their in-vitro affinity towards the 5- HT6 receptor is the subject matter of this communication.


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