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Synthesis and biological screening of new 4-substit uted-2-(3,4,5- trimethoxyphenyl)quinazolines as potential anticanc er agents | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Synthesis and biological screening of new 4-substit uted-2-(3,4,5- trimethoxyphenyl)quinazolines as potential anticanc er agents

Author(s): Ehab M. Gedawy and Zeinab Mahmoud*

Cancer is an umbrella term including a diversity of diseases. The need for new anticancer agents is a necessity. On the other hand, quinazolines are biologically inter esting scaffold. 4-substituedamino-2-(3,4,5- trimethoxy)quinazolines were synthesized using anth ranilamide as a starting material. Thirteen novel 2 -(3,4,5- trimethoxyphenyl)quinazolines 4a-d and 5a-h were synthesized. The NCI - USA has chosen seven c ompounds namely 5a and 5c-h of the new quinazoline derivatives for the 60-cell lines screening. Compound 5c showed null growth percent towards the melanoma MDA-MB-435 cell line. The IC 50 for 5c was also investigated for both non- small cell lung cancer cell line A549 and colon can cer cell line HCT116. The results were 8.57 and 10. 10 μ M/ml respectively.


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