GET THE APP

Synthesis and biological studies of novel chlorophenyl-(pyridinyl)- methylamine hydrochloride derivatives | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

ilbet

süperbetin giriş

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

agariookey oyna istanbul okey

Abstract

Synthesis and biological studies of novel chlorophenyl-(pyridinyl)- methylamine hydrochloride derivatives

Author(s): Madupu Purushotham, Katragadda Vekateswara Rao, Maddineni Arunakumari and Chunduri Venkata Rao

A series of novel chlorophenyl-(pyridinyl)-methylamine hydrochloride salts [1a-1c, 2a-2c, 3a-3c] are synthesized by the reduction of chlorophenyl-(pyridinyl)-methanone oxime derivatives [8a-8c] using zinc in acetic acid. Nucleophilic addition of chlorophenyl magnesium bromide [5a-5c] to pyridine carboxaldehyde [4a-4c] in dry THF using Grignard’s protocol provided corresponding chlorophenyl-(pyridinyl)-methanol derivatives [6a-6c] and former chlorophenyl-(pyridinyl)-methanone derivatives [7a-7c] are obtained by the oxidation using with chromium trioxide in acetic acid followed reaction with hydroxylamine hydrochloride to afford the chlorophenyl- (pyridinyl)methanoneoxime derivatives [8a-8c]. The structures of these newly synthesized [1a-1c, 2a-2c, 3a-3c] compounds were characterized by spectral data. The prepared compounds have been screened in vitro for their antibacterial activity using agar diffusion method.


PDF

rokettube brazzers

https://pmasites.com/https://casinositeleriniz.com/https://fbhesq.com/

https://paperio-live.com

wowcappadocia.com
cappadocia-hotels.com
https://babesoflondon.com/
balloon-rides.net

wormax io