Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry


Synthesis and biological studies of novel chlorophenyl-(pyridinyl)- methylamine hydrochloride derivatives

Author(s): Madupu Purushotham, Katragadda Vekateswara Rao, Maddineni Arunakumari and Chunduri Venkata Rao

A series of novel chlorophenyl-(pyridinyl)-methylamine hydrochloride salts [1a-1c, 2a-2c, 3a-3c] are synthesized by the reduction of chlorophenyl-(pyridinyl)-methanone oxime derivatives [8a-8c] using zinc in acetic acid. Nucleophilic addition of chlorophenyl magnesium bromide [5a-5c] to pyridine carboxaldehyde [4a-4c] in dry THF using Grignard’s protocol provided corresponding chlorophenyl-(pyridinyl)-methanol derivatives [6a-6c] and former chlorophenyl-(pyridinyl)-methanone derivatives [7a-7c] are obtained by the oxidation using with chromium trioxide in acetic acid followed reaction with hydroxylamine hydrochloride to afford the chlorophenyl- (pyridinyl)methanoneoxime derivatives [8a-8c]. The structures of these newly synthesized [1a-1c, 2a-2c, 3a-3c] compounds were characterized by spectral data. The prepared compounds have been screened in vitro for their antibacterial activity using agar diffusion method.