Synthesis and characterization of 2-[(8-hydroxyquinolinyl)-5-aminomethyl]-3-(4-methoxy phenyl)-3(H)-quinazolin-4-one ligand called HAMQ (HL3) was studied. To prepare this ligand anthranilic acid was converted into 2-chloromethyl–3(4-methoxy phenyl)-3(H)-quinazoline-4- one. This compound was finally condensed with 5-amino-8-hydroxyquinoline. The transition metal complexes of Cu2+, Ni2+, Zn2+, Mn2+ and Co2+ of this ligand HAMQ were prepared and characterized by reflectance, NMR as well as IR spectroscopy, elemental analysis and magnetic measurements. The stoichiometry of the complexes has been found to be 1: 2 (Metal : ligand). The data suggested an octahedral geometry around Co2+, Ni2+ and Mn2+ complexes, a distorted octahedral geometry around Cu2+ and a tetrahedral geometry around Zn2+ have been proposed. These complexes have been tested for their antifungal activities.
Select your language of interest to view the total content in your interested language
Der Pharma Chemica received 11575 citations as per Google Scholar report