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Synthesis and Characterization of (3S, 4R)-4-(4-Fluorophenyl)-Piperidine-3-Methanol, a Possible Impurity in Paroxetine Hydrochloride | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Abstract

Synthesis and Characterization of (3S, 4R)-4-(4-Fluorophenyl)-Piperidine-3-Methanol, a Possible Impurity in Paroxetine Hydrochloride

Author(s): Bhaskar H Zaware, Laki P Magar, Kishor R More, Mukesh S Jha

(3S, 4R)-trans-4-(4-fluorophenyl)-3-hydroxymethyl-1-methyl-piperidine is treated with methane sulfonyl chloride to convert in to mesityl derivative and then reacted with phenyl chloroformate to form carbamate derivative and finally hydrolyse to yield (3S, 4R)-4-(4-Fluuorophenyl)Piperidine-3-methanol.


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