Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Synthesis and characterization of 4-{4-[2-phenyl-4-(4-hydroxybenzylidene)-5-oxo-imidazol-1-yl]phenyl}-6-(substituted phenyl)- 5,6-dihydropyrimidin-2-one and study of their antimicrobial activities

Author(s): Amee B. Patel and Pankaj S. Patel

4-{4-[2-phenyl-4-(4-hydroxybenzylidene)-5-oxo-imidazol-1-yl]phenyl}-6-(substitutedphenyl)- 5,6-dihydropyrimidin- 2-one have been prepared by the refluxation for 3 hours of 4-(4-hydroxybenzylidene)-1-{4-[3- (substitutedphenyl)prop-2-enoyl]phenyl-2-phenyl-imidazol-5-one with urea and potassium hydroxide in presence of ethanol . The intermediate 4-(4-hydroxybenzylidene)-1-{4-[3-(substitutedphenyl)prop-2-enoyl]phenyl-2-phenylimidazol- 5-one synthesized by the condensation of 1-(4-acetylphenyl)-4-(4-hydroxybenzylidene)-2-phenylimidazol- 5-one with various aldehydes.


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