Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Synthesis and characterization of new 1,2-diazepine derivative

Author(s): Majal Sapnakumari, Badiadka Narayana, Seranthimata Samshuddin and Balladka Kunhanna Sarojini

The reaction of (1Z)-1-[(2E)-3-(4-bromophenyl)-1-(4-fluorophenyl)prop-2-en-1-ylidene]-2-(2,4-dinitrophenyl) hydrazine (2) with ethyl chloroacetate in the presence of base affords a new 1,2-diazepine derivative, 5-(4- bromophenyl)-1-(2,4-dinitrophenyl)-3-(4-fluorophenyl)-1H-1,2-diazepin-6-ol (3). The intermediate 2 in turn prepared from 4-bromo-4'-fluorochalcone (1). The structure of the newly synthesized compound is characterized by IR, NMR and mass spectral data


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