Synthesis and Characterization of New Schiff Bases and Biological Studies | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Synthesis and Characterization of New Schiff Bases and Biological Studies

Author(s): Abduljaleel Muhammad*, Nadia A. Hussein Al-Assady and Jasim Alshawi

A new Schiff bases compound has been synthesized by reaction ethylene diamine, with three new types of diketone compounds synthesized from condensation reactions of benzaldehyde, furan-2-carbaldehyde, and pyridine-2-carbaldehyde. The chemical composition and functional group identification of the synthesized compounds were confirmed by mass spectroscopy and 1HNMR spectroscopy. Preparation of Schiff base compounds (A2en, B2en, and C2en) in absolute ethanol using a solution of 0.2mole ethylene diamine in 25 ml methanol. Melting point, FT-IR, EI-Mass, H-NMR, and 13C-NMR spectroscopy, have been used to classify these compounds. Schiff base compounds (A2en, B2en, and C2en) were used for antibacterial activity in this study. The results proved that all Schiff base compounds provided good inhibition zones against gram-positive and gram-negative bacteria, especially in concentrations 300mg/ml of Schiff base compound B2en with diameter inhibition zone 19-20 mm against gram-negative bacteria and C2en with diameter inhibition zone 15-19mm against gram-positive and gram-negative bacteria respectively.

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