Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry


Synthesis and characterization of novel 2,2-di(pyridin-2-yl)hexahydropyrimidine and its derivative5,5-dimethyl-1,3-bis[(methylsulfonyl)oxy]-2,2-dipyridin-2-ylhexahydropyrimidine

Author(s): Mohammed Suleiman, Lamees Odeh, Rachid Salghi, Smaail Radi, Belkheir Hammouti, Anas Al-Ali, Ismail Warad

2,2-di(pyridin-2-yl) hexahydropyrimidine heterocyclic compound was prepared by condensation reaction of 1,3- propanediaminewith di(pyridin-2-yl)methanone1.5,5-dimethyl-1,3-bis[(methyl sulfonyl)oxy]-2,2-dipyridin-2- ylhexahydropyrimidine2 was prepared by protection of both N-H groups in2 using MeSO3Cl reagent in pyridine/THF media.The prepared compounds revealed good thermal stability, and simple one step decomposition mechanism. The condensation reaction to prepare 1has been monitored by IR.The structures