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Synthesis and characterization of novel 2-[(5Z)-5-benzylidene-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]-N-(2-methylphenyl)acetamide based analogues | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Synthesis and characterization of novel 2-[(5Z)-5-benzylidene-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]-N-(2-methylphenyl)acetamide based analogues

Author(s): Aniruddhasinh M. Rana, Kishor R. Desai, Smita Jauhari

In the present communication several 2-[(5Z)-5-benzylidene-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]-N-(2- methylphenyl)acetamide based small analogues have been synthesized by an efficient synthetic protocol. Variation in the functional group at 5-benzylidine ring of rhodanine led to set of 15 compounds bearing substituted N-phenyl acetamide accommodated 2-thioxo-4-thiazolidinone moiety. The chemical structures of the final synthesized compounds were confirmed by IR, 1H NMR, 13C NMR spectroscopy, ESI Mass spectrometry and elemental analysis.


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