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Synthesis and characterization of novel benzothiophene substituted oxadiazole derivatives and their antimicrobial activity. | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Synthesis and characterization of novel benzothiophene substituted oxadiazole derivatives and their antimicrobial activity.

Author(s): H. K. Nagesh, Basavaraj Padmashali, C. Sandeep, T. E. Musturappa and M. R Lokesh

The compound 2 was refluxed with various acetophenones and benzaldehydes to produce Schiff’s bases 4a-e and 6a-e. The reaction of these Schiff’s bases with acetic anhydride and phosphorous oxychloride to give benzothiophene linked 2, 5-disubstituted-1,3,4-oxadiazoles 5a-e and 7a-e. The compound 2 was directly cyclized by refluxing with phosphorus oxychloride to give benzothiophene substituted oxadiazoles 3a-e. All the newly synthesized compounds were screened for their antimicrobial activity and were characterized by elemental analyses, IR, 1H NMR and mass spectral data.


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