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Synthesis and characterization of novel N-(4-methyl-2-oxo-2H-chrome-7-yl)-2- (5-phenylsubstituted-1,3,4-oxadiazol-2-ylthio)acetamide derivatives | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Abstract

Synthesis and characterization of novel N-(4-methyl-2-oxo-2H-chrome-7-yl)-2- (5-phenylsubstituted-1,3,4-oxadiazol-2-ylthio)acetamide derivatives

Author(s): N. Hari Krishna, K.Vasu, K. Nagaraju, C. Venkata Rao

In the present study, we have synthesized a series of N-(4-methyl-2-Oxo-2H-chrome-7-yl) -2-(5-phenylsubstituted- 1,3,4-oxadiazol-2-ylthio) acetamide derivatives (1a-h) by the nucleophilic substitution of 2-chloro-N-(4-methyl-2- Oxo-2H-chrome-7-yl) acetamide (7) with suitable 1,3,4-oxadiazole- 2-thiols (5a-h). The chemical structures of the compounds were characterized confirmed by the IR, 1H-NMR, 13C-NMR and LC-MS spectral data.


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