Synthesis and characterization of Novel Related Substances of Lumefantrine, an anti-malarial drug | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.


Synthesis and characterization of Novel Related Substances of Lumefantrine, an anti-malarial drug

Author(s): Madhuresh Kumar Sethi, Anantavena Rani Gonuguntla, Siva Lakshmi Devi Arikatla, Suryanarayana Mulukutla, Rajakrishna Yerramalla, Jaganmohanarao Bontalakoti, Lakshminarayana Vemula and Jayaprakash Thirunavukarasu

Structural characterization related substances of Lumefantrine using IR, NMR data (1H & 13C NMR & MS). During the process development of Lumefantrine, a known antimalarial drug, six related substances were identified. All the six impurities were subsequently synthesized and characterized by IR, NMR and MS spectral data. The six related substances are known as 1-[(9Z)-2,7-dichloro-9-(4-chlorobenzylidene)-9H-fluoren-4-yl]-2-(diethylamino)ethanol 6, 2-(butylamino)-1-[(9Z)-2,7-dichloro-9-(4-chloro benzylidene)-9H-fluoren-4-yl]ethanol 7, 2,7-dichloro-4-[2-(dibutyl amino)-1-hydroxyethyl]-9H-fluoren-9-one 8, 1-[(9Z)-9-benzylidene-2,7-dichloro-9H-fluoren-4-yl]-2-(dibutylamino) ethanol 9, 2-(dibutylamino)-1-[(9Z)-2,7-dichloro-9-(3-chlorobenzylidene)-9H-fluoren-4-yl]ethanol 10, and 2- (dibutylamino)-1-[(9Z)-2,7-dichloro-9-(2-chlorobenzylidene)-9H-fluoren-4-yl]ethanol 11. The present work describes the formation, synthesis and characterization of these impurities. By controlling these new six process related substances will make this high doses anti-malarial drug safer for human use


Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Google Scholar citation report
Citations : 25868

Der Pharma Chemica received 25868 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry