Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry


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Synthesis and characterization of novel thiazole derivatives of disubstituted N-arylmaleimides

Author(s): Sunita A. Chaudhari (Patil), Vasant M. Patil, Satish M. Chavan, Sambhaji V. Patil, Jayraj S. Aher, Raghunath B. Toche and Madhukar N. Jachak

The compound 1 was reacted with bromine in DMF to obtained dibromosuccinimides 2.The compound 2 react with morpholine followed dehydrohalogenation to obtained monobromo compound, 3throughcommon enaminone intermediate. Vilsmeier Haack formylation of 3 afforded compound 4with good yield. Thus condensation of 1-(4- chlorophenyl)-2,5-dihydro-2,5-dioxo-4-(dialkyl-1-yl)-1Hpyrrole-3-carbaldehyde 4with thiosemicarbazide in ethanol in presence of acetic acid furnished compound 5with 88% yield. The compound 5 react with substituted phenacyl bromide 6 a-g to obtained thiazole derivative of disubstituted N-arylmaleimides 7 a-g.All the synthesized compounds were well characterized by IR, NMR and elemental analysis given in experimental section.


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