Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
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Abstract
Synthesis and characterization of o-hydroxyarylalkylketones by using eco-friendly solvent free catalyst in frie�s rearrangement
Author(s): Prashant B. Chouke, Vishwas N. IngleThe Fries rearrangement of aromatic esters is usually performed in Lewis acid (AlCl3), we have optimized this reaction with p-toluene sulphonic acid (PTSA). It was found to be as efficient new reagent for probing the mechanism of acylation reactions and Fries rearrangement of aromatic esters. PTSA is a strong, stable and biodegradable acid giving high conversion and selectivity (up to 90% of ortho-isomer and 10% of para-isomer at 100% conversion), Further, the conversion was confirmed by elemental and spectral (IR, 1H NMR Mass) analyses.
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Citations : 25868
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