Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

Abstract

Synthesis and characterization of potent Abacavir impurities

Author(s): G. V. Satyanarayana, M. Thirumala Chary, E. Laxminarayana

A general and efficient synthesis of carbocyclic and hexenopyranosyl nucleosides has been developed. Abacavir and its derivatives as well as hexenopyranosyl nucleoside analogues have been prepared by this sequence. All compounds were purified by column chromatography and were characterized by IR, 1H NMR, 13C NMR and by mass spectral analyses.