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Synthesis and characterization of process-related impurities of an anti-hyperuricemia drug-Febuxostat | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Synthesis and characterization of process-related impurities of an anti-hyperuricemia drug-Febuxostat

Author(s): Venkateswara Rao Vallu, Krunal Girishbhai Desai, Sandip Dhaya Patil, Rajendra Agarwal, Pratap Reddy Padi, Mahesh Reddy Ghanta

Febuxostat is a urate-lowering drug, indicated for the treatment of hyperuricemia and gout. During the process development of febuxostat, nine process related impurities were observed at a level of 0.1-0.15 area percent. Synthesis and characterization of these impurities and investigation of their formation is described.


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