Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Synthesis and characterization of pyrazoline derivatives obtained from 4-bromo-naphthalen-1-ol

Author(s): V. M. Sherkar and S. E. Bhandarkar

1-(4-bromo-1-hydroxynaphthalen-2-yl)-ethanone have been synthesized from 4-bromo-naphthalen-1-ol by refluxing it with glacial acetic acid in presence of fused ZnCl2 by modified Nenchis method. 1-(4-bromo-1-hydroxynaphthalen- 2-yl)-3-aryl-prop-2-en-1-one were synthesized from 1-(4-bromo-1-hydroxy naphthalen-2-yl)-ethanone by condensing it with aromatic aldehydes. Then these newly synthesized 1-(4-bromo-1-hydroxy-naphthalen-2-yl)-3- aryl-prop-2-en-1-one were cyclized with nucleophiles like phenyl hydrazine / semicarbazide / thiosemi carbazide in DMF solvent and refluxed for 2 hours . The cooled reaction mixture was diluted with water the semisolid so obtained was triturated with ethanol to get a solid which was recrystallised from ethanol–acetic acid mixture to get pyrazoline derivatives. The synthesized compounds were characterized by elemental analysis, 1H NMR, IR Spectroscopy.


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