Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

Abstract

Synthesis and characterization of Schiff base metal complexes derived from imidazole-2-carboxaldehyde with L-phenylalanine

Author(s): R. Selwin Joseyphus, C. Shiju , J. Joseph, C. Justin Dhanaraj and K. C. Bright

The Schiff base ligand, derived from imidazole-2-carboxaldehyde with L-phenylalanine and the Co(II), Ni(II), Cu(II) and Zn(II) complexes were synthesized. The synthesized ligand and its complexes were characterized by elemental analysis, molar conductance, magnetic moment, 1H NMR, 13C NMR, IR, UV-Vis., ESR, mass spectra, TGA, CV and powder XRD. The analytical data shows that the metal to ligand ratio is 1:1. The molar conductance data reveal that all the complexes are non-electrolytes. The results show that the ligands act as a tridentate monobasic donor coordinating through the azomethine nitrogen, imidazole nitrogen and carboxylato oxygen atoms. The TGA data indicates the presence of coordinated water molecules in these complexes. The crystallinity of these compounds was proved by the powder XRD pattern. Antimicrobial studies indicate that the complexes exhibit more activity than the ligand.


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