There are many substituted pyridines having simple structures and greater pharmacological importance e.g. Nicotinamide, Nicotinic acid, 4- Amino pyridine and Isoniazid etc. Two drugs can be given simultaneously to the patient in the form of Twin Drugs in order to minimize the dose and side effects. Because of increase in lipophilicity, bioavailability is increased. Taking the same principle various non-identical twin drugs have been synthesized. Nicotinic acid has been combined with Fampridine (1) and Isoniazid (2), all used in the treatment of multiple sclerosis. Nicotinic acid has been combined with Salicylic Acid (3), both used in the treatment of atherosclerosis. PARP inhibitor i.e. Nicotinamide has been combined with COX inhibitor i.e. Aspirin(4),having anti-inflammatory activity. Partition co-efficient was also determined which showed that by making twin drugs, Lipophilicity and hence bioavailability is increased and dosing frequency and side effects are decreased.
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