A series of potentially active quinoline based bisphenols has been synthesized by simple and efficient synthetic protocol. The quinoline based bisphenol, 4-((4-hydroxyphenyl)(quinolin-4-yl)methyl)phenol formed from quinoline- 4-carbaldehyde and phenol in acetic acid medium followed by reaction with various substituted methyl groups. The newly synthesized bisphenols has an aromatic amine part which is fluorescence active and also can act as a binding site. The quinoline based bisphenols act as chemosensor when on addition of indium ion(+3), the curve is shifted towards the longer wavelength as well as the intensity of fluorescence emission spectra has been increased. The structure of the final analogues has been confirmed on the basis of 1HNMR, IR and Mass analysis.
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