Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.


Synthesis and characterization of some substituted pyrazoles as analgesics and anti inflammatory agents

Author(s): Shilpa Ailawadi, Jyoti, Mithlesh Yadav and Devender Pathak

A convenient synthesis of some new substituted 3,5- dimethyl pyrazole (4a-c), 3-methyl pyrazol-5-one derivatives (5a-c), 3-Methyl-1-(substituted phenyl) pyrazol-5-ones (7a-b) and 2,3-dimethyl-1-(substituted phenyl)pyrazol-5-ones (8a-b) have been synthesized. All the newly synthesized compounds were tested for their in vivo anti-inflammatory and analgesic activity by bioassays namely: Carrageenan-induced paw edema method and acetic acid induced writhing method respectively. All the synthesized compounds have been characterized by their melting point, elemental analysis, IR and 1H-NMR. Compound 8b exhibited promising and significant inhibitory activity against COX-2 enzyme. Therefore, such compounds would represent a fruitful matrix for the development of anti-inflammatory and analgesic agents.


SCImago Journal & Country Rank
Recommended Conferences
bornova escort karşıyaka escort osmangazi escort buca escort anne porno fetiş porno anal porno bartın escort burdur escort eskişehir escort escort izmir bursa escort porno escort bayan