Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry


Synthesis and Characterization of Tetrasubstitued Imidazole by Using Silica Supported Catalysis

Author(s): Sarnikar YP, Mane YD, Survarse SM, Khade BC

A facile route for the synthesis of tetrasubstituted imidazole has been developed; the one pot synthetic protocol allows the efficient synthesis of biologically important scaffolds. By using alkyne as the key starting material, which was oxidized in situ to get active carbonyl species? The key reaction involved in this synthesis is formic acid catalyzed oxidation, I2 mediated oxidation and Silica supported cyclization to give tetrasubstituted imidazole.