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Synthesis and Cytotoxic Activity Evaluation of Novel Piperazine-quinoline Derivatives on Brest cancer Cell Lines | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Synthesis and Cytotoxic Activity Evaluation of Novel Piperazine-quinoline Derivatives on Brest cancer Cell Lines

Author(s): S. Sekar, Nagaraja Naik, AM Sridhara and S Yogisha

A series of new piperizine-quinoline derivatives (RB1-10) were designed and synthesized from 4- (bromomethyl)quinolin-2(1H)-one and arylpiperazines. The structure of newly synthesized compounds were characterized by spectral data’s and screened for their cytotoxic activity against barest cancer cell lines. The compound RB1 with trifluoromethoxy substitution on aryl group showed moderate activity.


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