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Synthesis and docking studies of 4-aryl-1-phenyl-1H-pyrazol-5-ylimino-2-methoxy phenyl acetate as antibacterial agents | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Synthesis and docking studies of 4-aryl-1-phenyl-1H-pyrazol-5-ylimino-2-methoxy phenyl acetate as antibacterial agents

Author(s): Bharatkumar M. Sapkal and Dhananjay H. More*

4-Aryl-1-phenyl-1H-Pyrazol-5-ylimino-2-methoxyPhenol has been synthesized by condensation of 4-Aryl-5-amino pyrazol and Vanillin. 4-Aryl-1-phenyl-1H-Pyrazol-5-ylimino-2-methoxyPhenol further acylated using different acylating agent viz acetyl chloride, benzoyl chloride, p-nitro benzoyl chloride, p-tolyl benzoyl chloride. Structure elucidation of the synthesized compounds was done based on analytical and spectral data. Synthesized compounds were evaluated for their antimicrobial activity against Pseudomonas, E. coli, S. aureus and Bacillus subtilis. Compounds 5c, 5i and 5k showed the equipotent activity compared with Chloramphenicol and Cephalothin as reference drugs. Docking studies of the promising compounds was done on MurB using Hex 6.3 docking program to study their observed activity.


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