Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Synthesis and evaluation of acetaminophen derivatives as analgesic, antipyretic and anti-inflammatory agents

Author(s): Ramesh Kumar, Sandeep Jain and Neelam Jain

In the present study, Dicarboxylic acid bis (4-acetylaminophenyl) ester (AP1-AP4) and (4-acetylaminophenoxy) acetic acid (AP-5) have been synthesized by the reaction of acetaminophen with dicarboxylic acid chlorides and chloroacetic acid, respectively. The esterification of (4-acetylaminophenoxy) acetic acid with different alcohols yielded rest of the compounds (AP6-AP13). The characterization of the compounds was done by IR, 1H NMR and elemental analysis. All the synthesized compounds were screened in vivo for analgesic, antipyretic and antiinflammatory activities. Appreciable activities were observed for many compounds.


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