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Synthesis and evaluation of antifungal activity of 5-chloro-1-methyl-2-?Ž?±-[(N4-aryl) piperazin-1-yl] ethyl benzimidazoles | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Abstract

Synthesis and evaluation of antifungal activity of 5-chloro-1-methyl-2-?Ž?±-[(N4-aryl) piperazin-1-yl] ethyl benzimidazoles

Author(s): Rahul B. Ghuge, Sanjay J. Kshirsagar, Dinesh D. Rishipathak, Sonali S. Ugalmugale, Shweta S. Pekhale and Priyanka S. Niphade

The availability over the past 2 decades of the azole antifungal agents represents a major advance in management of systemic fungal infections. Like miconazol, fluconazole itraconazlole. These drugs having some drawbacks like interaction with co administered drugs, emergence of resistance of fungal organisms. From the limitations of therapeutically available benzimidazole containing antifungal agents and previous experiences of our department, we have synthesized different substituted aryl piperazines, 5-chloro-1-methyl-2-[α-(chloro) piperazin-1-yl ethyl benzimidazole nucleuses and condensed them to offer targeted compounds. Compounds were characterized by IR, 1H NMR. All the compounds were tested for their antifungal activity against fungal strain of Candida albicans. Most of the compounds showed moderate to good anti-fungal activity


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