GET THE APP

Synthesis and evaluation of new polysubstituted quinazoline derivatives as potential antimicrobial agents | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

Abstract

Synthesis and evaluation of new polysubstituted quinazoline derivatives as potential antimicrobial agents

Author(s): Yaser A. El-Badry, Naglaa A. Anter, Huda S. El-Sheshtawy

A new series of polysubstituted quinazoline derivatives has been furnished as a product of N-acylation, O-acylation and/or O-alkylation of the corresponding 2-methylquinazolinones; based on using the principles of lactam-lactim dynamic equilibrium phenomena and the role of solvent polarity in shifting such equilibrium. The reaction of the prepared polysubstituted quinazolines with different nitrogen, carbon, and sulphur nucleophiles has produced derivatives of 4-heteroaryl-quinazoline derivatives and interesting moieties such as oxadiazoles, triazoles, fused triazolo-thiadiazole, thiazole, furyl, and pyrazole were introduced at the 4-position of the quinazoline skeleton. Some of the synthesized compounds are tested for its antimicrobial activity.


PDF

Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Recommended Conferences

14th World Congress on Chemistry
Barcelona, Spain

19th European Organic Chemistry Congress
London, UK
Google Scholar citation report
Citations : 11575

Der Pharma Chemica received 11575 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry