Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Synthesis and evaluation of new pyrazolines of benzimidazole as potent analgesic and antiinflammatory agents

Author(s): Sharmila A. Gote, B. Shivkumar and Gaviraj E. L.

A series of 7-chloro-2-[3-(1h-benzimidazol-2-yl)-5-aryl-4,5-dihydro-1H-pyrazol-1-yl]-6-fluoro-1,3-benzothiazole (VI) was synthesized by the action of 7-chloro-6-fluoro-2-hydrazino-1,3-benzothiazole (V) on chalcones in the presence of catalytic amount of glacial acetic acid and ethanol. The structures of the synthesized compounds have been established on the basis of their elemental analysis and spectral (IR,1HNMR) studies. Further they have been screened for their anti-inflammatory and analgesic activity.


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