Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Synthesis and In Silico Research of Derivatives of 3-allyl-4-(R-phenyl)-N-(R1-phenyl)-thiazole-2-imine

Author(s): Perekhoda LO, Drapak IV, Suleiman MM, Sych IA, Yaremenko VD

The synthesis of those new derivatives of 3-allyl-4-(R-phenyl)-N-(R1-phenyl)-thiazole-2-imine was conducted which consist substituted aromatic radicals. Structure of the compounds synthesized has proved by means of a comprehensive use of modern physical and chemical methods of analysis. In silico research has been conducted of the potential molecular mechanisms of cardioprotective action of the obtained substances with the method of a soft molecular docking, and recommendations to the rational design of the ligands have been made.


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