Synthesis and In vitro antimicrobial evaluation of some novel bioactive heterocyclic compounds | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.


Synthesis and In vitro antimicrobial evaluation of some novel bioactive heterocyclic compounds

Author(s): Bhavnaben D. Mistry, Kishor R. Desai and Nigam J. Desai

4-(2,5-Dichloro-3-Thienyl)-6-Aryl Pyrimidine -2-Amine 2a-m , 7-Chloro-N-[4-(2,5-dichloro-3-thienyl)-6-Aryl pyrimidine-2-yl] quinoline -4-amine 3a-m and 4-(2,5-dichloro thiophen-3-yl)-2-aryl benzo[1,4]thiazepine 4a-m have been synthesized from (2E)-3-aryl-1-(2,5-dichloro-3-thienyl)prop-2-en-1-one 1a-m by the cyclization with guanidine nitrate and then condensation with 4,7-dichloroquinoline(2a-m , 3a-m) and cyclization with o-amino thiophenol respectively (4a-m ). Compounds (2E)-3-aryl-1-(2,5-dichloro-3-thienyl)prop-2-en-1-one 1a-m was synthesized from 1- (2,5-dichloro thiophen-3-yl)-ethanone and various aromatic aldehyde. The structures of novel synthesized compounds have been established on the basis of IR , 1 H NMR, 13 C NMR and Mass spectral data and screened for their antimicrobial activities against different microorganisms by micro dilution method. Isoniazid, Rifampicin, chloroquine, quinine, Gentamycin, Ampicilin, Chloramphenicol, Ciprofloxacin, Norfloxacin, Nystatin and Greseofulvin were used as standard drugs for mycobacteria H37Rv, malarial parasite P.falciparum , bacteria E.coli, P.aeruginosa, S.aureus, S.pyogenus and fungus C.albicans, A.niger, A.clavatus.


Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Recommended Conferences

14th World Congress on Chemistry
Barcelona, Spain

19th European Organic Chemistry Congress
London, UK
Google Scholar citation report
Citations : 11575

Der Pharma Chemica received 11575 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry