4-(2,5-Dichloro-3-Thienyl)-6-Aryl Pyrimidine -2-Amine 2a-m , 7-Chloro-N-[4-(2,5-dichloro-3-thienyl)-6-Aryl pyrimidine-2-yl] quinoline -4-amine 3a-m and 4-(2,5-dichloro thiophen-3-yl)-2-aryl benzo[1,4]thiazepine 4a-m have been synthesized from (2E)-3-aryl-1-(2,5-dichloro-3-thienyl)prop-2-en-1-one 1a-m by the cyclization with guanidine nitrate and then condensation with 4,7-dichloroquinoline(2a-m , 3a-m) and cyclization with o-amino thiophenol respectively (4a-m ). Compounds (2E)-3-aryl-1-(2,5-dichloro-3-thienyl)prop-2-en-1-one 1a-m was synthesized from 1- (2,5-dichloro thiophen-3-yl)-ethanone and various aromatic aldehyde. The structures of novel synthesized compounds have been established on the basis of IR , 1 H NMR, 13 C NMR and Mass spectral data and screened for their antimicrobial activities against different microorganisms by micro dilution method. Isoniazid, Rifampicin, chloroquine, quinine, Gentamycin, Ampicilin, Chloramphenicol, Ciprofloxacin, Norfloxacin, Nystatin and Greseofulvin were used as standard drugs for mycobacteria H37Rv, malarial parasite P.falciparum , bacteria E.coli, P.aeruginosa, S.aureus, S.pyogenus and fungus C.albicans, A.niger, A.clavatus.
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