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Synthesis and in vitro biological activity of 6-chloro-pyridin-2-yl-amine derivatives | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Synthesis and in vitro biological activity of 6-chloro-pyridin-2-yl-amine derivatives

Author(s): S. Nagashree, L. Mallesha and P. Mallu

6-Chloro-pyridin-2-yl-amine derivatives 3(a-h) were synthesized by using 2-amino-6-chloropyridine (1) as starting material. The newly synthesized compounds were characterized by elemental analyses, 1H NMR and mass spectral studies. The synthesized compounds were screened for antibacterial and antifungal activities. All the synthesized compounds showed the antibacterial activity against four pathogenic strains of Bacillus subtilis (MTCC 121), Staphylococcus aureus (MTCC 7443), Xanthomonas campestris (MTCC 7908), Escherichia coli (MTCC 7410) and antifungal activity against pathogenic strains of Fusarium oxysporum (MTCC 2480). All compounds showed good to moderate antimicrobial activity. However, compounds 3a, 3f and 3h showed potent antibacterial activity against pathogenic strains used in the study.


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