Novel dihydropyrimidine derivatives were synthesized and evaluated for their calcium channel blocker activity. Synthesis involves the modification of dihydropyrimidine (DHPM) pharmacophore with thiosemicarbazide, semicarbazide and hydrazide functions. The calcium channel blocker effect was tested on rat ileum by taking cumulative responses of the test compound on KCl (60mM) - induced contracted rat ileum. Among all the synthesized compounds, DHPMs with semicarbazide residue have shown the most significant activity. Among semicarbazides series, compound 6C was found to show potent Calcium channel blocker activity.