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Synthesis and Larvicidal Activity of Morpholinophenyl and Benzyl-Fluoro Pyrimidine Derivatives | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Synthesis and Larvicidal Activity of Morpholinophenyl and Benzyl-Fluoro Pyrimidine Derivatives

Author(s): Satya Kumar Avula, Shashi Kanth Boddu and Prashanthi Yarasani*

A series of 5-fluoro-N4-(3-(4-substitutedbenzylamino)phenyl)-N2-(4-morpholinophenyl) pyrimidine-2,4-diamine derivatives 7a-J were prepared and tested for their larvicidal activity against third instar larvae at 24, 48 and 72 hours and values were compared with Malathion as a positive control. Compounds 7a, 7c, 7f, 7g and 7i exhibited good larvicidal significant activity. Interestingly, compounds 7b, 7d, 7e, and 7h showed excellent activity very likely due to the presence of functional groups attached to the benzyl ring.


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