Synthesis and mass spectra of some new 3-substituted coumarin derivatives | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Synthesis and mass spectra of some new 3-substituted coumarin derivatives

Author(s): Jehan A. Hasanen

Reaction of 3-acetylcoumarin (1) with thiosemicarbazide gave the corresponding 3-acetylcoumarin thiosemicarbazone (2). Treatment of 2 with acetic anhydride, benzoyl chloride, ethyl chloroacetate, ω- bromomethylketones and dicarbonyl compounds afforded the corresponding diacetyl- and- dibenzoyl thiosemicarbazone derivatives (3,4), 3-(Coumarin-3-ylethylidene)amino-2-thioxo-imidazolidin-4-one (5) , 5-Aryl-2- [( coumarin-3-ylethylidene)-hydrazino]-thiazole (7) and 1-(Coumarin-3-ylethylidene) amino-2-thioxopyrimidine derivatives (8 and 9), respectively. The mass spectral fragmentation patterns of some prepared compounds have been investigated in order to elucidate the structure of the synthesized compounds.


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