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Synthesis and molecular modeling of new quinoline derivatives as antitumor agents | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Synthesis and molecular modeling of new quinoline derivatives as antitumor agents

Author(s): Lamiaa Osama, Laila A. Abou-Zeid, Magda N. A. Nasr and Atif S. Tantawy

A new series of quinoline containing compoundswasdesigned,synthesized and evaluated biologically for their invitro
antitumor activity. Compounds 7, 8,11, 12,17 and 18showed the best cytotoxic activity against five tumors cell lines
(HePG-2, HCT-116, MCF-7, PC3 and Hela) with IC50 range between 5.6-19.2 μg/ml. Molecular modeling studies
have been performed for the investigated compounds to evaluate their recognition profiles at the VGFR tyrosine
kinase binding-pocket.


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