GET THE APP

Synthesis and molecular modeling studies of novel tert-butyl 2, 4- disubstituted carboxamido phenylcarbamate derivatives and evaluation of their antimicrobial activity | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

Abstract

Synthesis and molecular modeling studies of novel tert-butyl 2, 4- disubstituted carboxamido phenylcarbamate derivatives and evaluation of their antimicrobial activity

Author(s): Jalapathi Pochampally*, Anil Valeru, Ramesh Macha, Bhavani A. K. D., Umapathi Nalla, Parthasarathy Tigulla, Bharath Gandu and Gangagnirao A.

A new series of novel tert-butyl 2,4-disubstituted carboxamido phenylcarbamate derivatives were synthesized and evaluated for their biological activities against three gram positive bacteria viz; Bacillus licheniformis, Bacillus subtilis, Staphylococcus aureus, three gram negative bacteria viz; Escherichia coli, Klebsiella pneumonia, Pseudomonas aeruginosa & four fungi strains viz; Aspergilus niger, Candida albicance, Fusarium oxysporum, Fusarium solani. All compounds were characterized by IR , 1H NMR, 13C NMR, MS and elemental analysis. Among all the title compounds 6b, 6c, 6e, 6g & 6h displayed the most potent antimicrobial activity. The compounds 6b & 6e showed highest antibacterial effect with respect to standard ciprofloxacin. The remaining analogues were showed good to moderate antibacterial activity. The compounds 6b, 6c & 6e showed promising antifungal activity with respect to standard Nystatin. The molecular docking studies were performed to newly synthesized carbamates (6a-k) into the active site of Mycobacterium tuberculosis enoyl reductase (InhA) complexed with 1-cyclohexyl-N-(3,5- dichlorophenyl)-5-oxopyrrolidine-3-carboxamide (2H7M), Candida albicans dihydrofolate reductase complexed with NADPH and 6-methyl-5-[3-methyl-3-(3,4,5-trimethoxyphenyl)but-1-yn-1-yl]pyrimidine-2,4-diamine (UCP115A) (3QLS) to determine the probable binding modes.


PDF

Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Google Scholar citation report
Citations : 23677

Der Pharma Chemica received 23677 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry