Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Synthesis and pharmacological screening of some new derivatives of (Z)-[2-(2-substituted benzalamino-4-yl) hydrazono]-indolin-2-ones

Author(s): N. Raghunandan, M.Aruna Devi, D. Sriram and M. Sarangapani

Five different (Z)-3-[2-(2- aminooxazol-4-yl) hydrazono]-indolin-2-ones were synthesized from respective 3-[N-(chloroacetyl) hydrazono] indolin-2-one on reaction with urea. Each of that compound has refluxed with different aromatic aldehydes to get the respective (Z)-3-[2-(2- substituted benzalamino oxazol-4-yl)hydrazono]-indolin-2-ones. All the new derivatives of) (Z)- 3-[2-(2-substituted benzalaminooxazol-4-yl) hydrazono]-indolin-2-ones were assayed for their antibacterial, antifungal, antioxidant and cytotoxic activities by standard methods


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