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Synthesis and pharmacological screening studies of some novel imidazo[2,1-b][1,3,4]thiadiazole | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Synthesis and pharmacological screening studies of some novel imidazo[2,1-b][1,3,4]thiadiazole

Author(s): Madhu Kumar Dogganal Jayappaa, Jagadeesh Prasad Dasappaa, Rejeesh Edavan Puthallathb and Prakash Anil Castelinoa

A series of novel heterocyclic systems 2-((6-(aryl)imidazo[2,1-b][1,3,4]thiadiazol-2-yl)thio)-N-(4- fluorophenyl)acetamide (4a-k) were obtained by heating 2-((5-amino-1,3,4-thiadiazol-2-yl)thio)-N-(4- fluorophenyl)acetamide (3) with various α-haloketones. The newly synthesized compounds were characterized by spectral techniques and evaluated for their antibacterial, antifungal, anthelmintic activity and in-vivo antiinflammatory, analgesic activities. The pharmacological results revealed that some of the tested compounds showed good activity


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