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Synthesis and pharmacology of some novel 4(3H)-quinazolinone derivatives | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Synthesis and pharmacology of some novel 4(3H)-quinazolinone derivatives

Author(s): Hemant Panwar, Shishupal Singh, Ashutosh Kumar, Sachi Singh, Nidhi Singh and Himanshu Singh

Several novel 4(3H)-quinazolinone derivatives incorporating four known bioactive moiety such as adamantine, piperazine, imidazolidine and thiazolidinone were synthesized by using multistep reaction strategy. The synthesized derivatives were characterized by IR, 1H-NMR, Mass and elemental analysis. Furthermore the synthesized derivatives evaluated for antibacterial, antifungal, anti-inflammatory, ulcerogenic, analgesic and acute toxicity activities.


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