Chalcones have been reported to possess vario us biological activities such as anti-inflamma tory, antioxidant, antitubercular, antibacterial activ ities. It is a basic moiety of many heterocy clic systems containing oxygen, sulphur and nitrogen. Nitro gen containing heterocyclic derivatives synthe sized from chalcones have exhibited anti-inflammatory, anti oxidant, antitubercular, antibacterial activitie s. Following Claisen-Schmidt condensation reaction, chloroacyl aminochalcones (I & II) were obtained by the reaction of chloroacetylamido acetophenones with substitute d benzaldehyde. The chlorine atom of (I and II) was replaced by various amines to obtain substitu ted aminoacetamidochalcones (I (a-d) and II (a-d) ) . The Characterization of newly synthesized compounds done on the basis of UV, IR, 1 HNMR, 13 CNMR, Mass spectral data as well as elemental analysis. All the Synthesized compounds were evaluated for their anti- inflammatory, antioxidant, antitubercular and antibacterial activities.