Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry


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Synthesis and Spectroscopic Studies of Novel Transition Metal Complexes with 5-Phenyl-2-[2-Hydroxy pyridylacethydrazide]-1,3,4-Oxadiazole

Author(s): Adil A Awad

A new Schiff base 5-Phenyl-2-[2-hydroxy benzylhydrizido]-1,2,4-oxadiazole (HL) and its complexes with (Cr(III), Mn (II), Ni (II), Co(II) and Cu (II) were synthesized. The ligand was prepared in two steps, in the first step a solution of 2- mercapto -5-phenyl-1,3,4–oxadiazole in methanol reacts with 98% hydrated hydrazine under reflux to give an intermediate compound 2-hydrazion-5-phenyl-1,3,4-oxadiazole which reacts in the second step with o-hydroxybenzaldehyde to give the mentioned ligand (HL). The complexes were synthesized by addition the corresponding metal chloride solution to solution of ligand in methanol under reflux (1:2) metal to ligand ratio. On the basis of molar conductance, magnetic susceptibility, I.R, UV–visible spectra and elemental analysis (C.H.N) the complexes may be formulated as [CrL2(H2O2]Cl and [ML2], where M: (Mn(II), Co(II), Ni(II) and Cu(II). The data suggested an octahedral geometry for Cr(III) complex and a square planar for Co(II), Ni(II) and Cu(II), while the Mn(II) complex was tetrahedral.


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