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Synthesis and spermicidal activity of substituted ( E)-3-(aryl/heteroaryl)-1- phenylprop-2-en-1-ones | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Synthesis and spermicidal activity of substituted ( E)-3-(aryl/heteroaryl)-1- phenylprop-2-en-1-ones

Author(s): Jatinder Vir Singh 1 , Sahil Sharma* 2 and Sandeep Rahar* 1

In the search of new and efficient spermicidal agen ts, substituted chalcones or 1,3-diaryl-2-propen-1- ones possessing acrylophenone moiety in their structural framework, have been synthesized by condensing ary l ketones with aromatic aldehydes under basic conditions via Claisen-Schmidt condensation. The synthesized compo unds were characterized by elemental analysis, 1 H and 13 C NMR. The prepared compounds have been screened fo r their spermicidal activity against human spermatozoa. Bio -evaluation studies of these molecules revealed tha t compound JS16 was the most potent spermicide among the serie s with MEC of 0.05 %. The present communication des cribes syntheses, bio-evaluation and structure-related spe micidal activity of (E)-3-(substitutedaryl/heteroar yl)-1- substitutedphenylprop-2-en-1-ones.


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